General Information

  • ID:  hor005422
  • Uniprot ID:  P83770
  • Protein name:  Insulin-like protein A chain
  • Gene name:  NA
  • Organism:  Vigna unguiculata (Cowpea)
  • Family:  insulin family
  • Source:  Plant
  • Expression:  Expressed in developing fruits between 4 and 20 days after pollination. Concentration decreases when fruits ripen. |Expressed in seed coats and pods.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Vigna (genus), Phaseoleae (tribe), indigoferoid/millettioid clade, NPAAA clade, 50 kb inversion clade, Papilionoideae (subfamily), Fabaceae (family), Fabales (order), fabids, rosids, Pentapetalae, Gunneridae, eudicotyledons, Mesangiospermae, Magnoliopsida (class), Spermatophyta, Euphyllophyta, Tracheophyta, Embryophyta, Streptophytina (subphylum), Streptophyta (phylum), Viridiplantae (kingdom), Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0005975 carbohydrate metabolic process; GO:0006006 glucose metabolic process; GO:0007165 signal transduction; GO:0008643 carbohydrate transport
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GIVEQXXASVXSLYQLENYXN
  • Length:  21(31-51)
  • Propeptide:  FVNQHLXGSHLVEALYLVXGERGFFYTPKAGIVEQXXASVXSLYQLENYXN
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  May be involved in the transport of sugars to the developing embryo in the fruit. May also be involved in signaling events.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005422_AF2.pdbhor005422_ESM.pdb

Physical Information

Mass: 265195 Formula: C85H123N21O26
Absent amino acids: CDFHKMPRTW Common amino acids: X
pI: 3.61 Basic residues: 0
Polar residues: 7 Hydrophobic residues: 6
Hydrophobicity: -15.71 Boman Index: -1947
Half-Life / Aliphatic Index: 30 hour Aliphatic Index: 88.1
Instability Index: 727.62 Extinction Coefficient cystines: 2980
Absorbance 280nm: 149

Literature

  • PubMed ID:  12937781
  • Title:  A protein with sequence homology to bovine insulin is found in the legume Vigna unguiculata (cowpea)